Pharmaceutical Structural Biology @ IMCA-CAT
The IMCA-CAT insertion device synchrotron beamline, designed with state-of-the-art equipment, is ideally suited for proprietary drug discovery research. Intense focused beam, robotics for sample mounting, diffraction rastering and high-speed precision sample positioning, and shutterless continuous-rotation data collection enable the beamline to meet the throughput demands of the pharmaceutical industry. Experiment design capabilities include wavelength tunability for MAD and SAD experiments, selectable mini beam for optimum beam size, and collect-along-a-vector for overcoming sample degradation.
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Discovery and lead optimization phases of drug development are significantly accelerated at IMCA-CAT with high quality, ultra fast data acquisition for pharmaceutical structural biology. Structural studies of the most challenging complexes, including membrane proteins, small crystals, and radiation-sensitive samples, benefit from advanced beamline capabilities. Fragment screening high-throughput demands are met with fully automated and fast processes for data acquisition. On-the-fly structural analyses are enabled by high-speed, secure, and encrypted data transfer to off-site locations for integrating with company-based pipelines.
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