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Pharmaceutical Structural Biology @ IMCA-CAT

The IMCA-CAT insertion device synchrotron beamline, designed with state-of-the-art equipment, is ideally suited for proprietary drug discovery research.

Intense focused beam, robotics for sample mounting, diffraction rastering and high-speed precision sample positioning, and shutterless continuous-rotation data collection enable the beamline to meet the throughput demands of the pharmaceutical industry.

Experiment design capabilities include wavelength tunability for MAD and SAD experiments, selectable mini beam for optimum beam size, and collect-along-a-vector for overcoming sample degradation.


  • intense, stable, mini beam
  • auto diffraction rastering
  • collect-along-a-vector
  • shutterless, continuous-rotation
  • auto data collection & processing
  • fast, encrypted data transfer~~



Discovery and lead optimization phases of drug development are significantly accelerated at IMCA-CAT with high quality, ultra fast data acquisition for pharmaceutical structural biology.

Structural studies of the most challenging complexes, including membrane proteins, small crystals, and radiation-sensitive samples, benefit from advanced beamline capabilities.

Fragment screening high-throughput demands are met with fully automated and fast processes for data acquisition.

On-the-fly structural analyses are enabled by high-speed, secure, and encrypted data transfer to off-site locations for integrating with company-based pipelines.


  • high-throughput
  • fragment screening
  • MAD/SAD phasing
  • small, weakly diffracting crystals
  • large macromolecular assemblies
  • membrane proteins none; margin:0; '>
    Each year, more than 17,000 structures are solved from data collected at the IMCA-CAT beamline.

Guaranteed, frequent, and routine access for proprietary data acquisition, whether on-site, remotely, or via mail-in, smoothly integrates with pharmaceutical drug design work flows.

The IMCA-CAT research facility is aimed at accelerating pharmaceutical drug discovery programs and performs to the highest standards of reliability, efficiency, and throughput.

  • proprietary experiments
  • guaranteed, frequent access
  • on-site, remote, mail-in
  • extremely productive
  • exceptionally reliable
  • highly efficient
  • outstanding quality